By T. Scott Stroup, Jeffrey A. Lieberman
Antipsychotic medicines are a key therapy for schizophrenia and revenues of antipsychotic medicines process $20 billion according to 12 months, with fierce advertising among the makers of the medicine. The U.S. nationwide Institute of psychological health and wellbeing subsidized the medical Antipsychotic Trials of Intervention Effectiveness (CATIE) venture to supply self sufficient information regarding the comparative effectiveness of medicines. CATIE was once the biggest, longest and such a lot finished learn of schizophrenia so far. performed lower than rigorous double-blind stipulations, Antipsychotic Trials in Schizophrenia provides the definitive archival result of this landmark research. The middle of the publication includes chapters fascinated about particular results that set the CATIE findings in a much wider context. additionally incorporated are chapters at the layout, statistical analyses and implications for researchers, clinicians and coverage makers. Psychiatrists, psychiatric researchers, psychological well-being coverage makers and people operating in pharmaceutical businesses will all locate this to be crucial interpreting.
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Additional resources for Antipsychotic trials in schizophrenia : the CATIE project
Briefly, all prospective research participants were screened for decision-making capacity using the MacArthur Competence Assessment Tool-Research (MacCAT-CR) . Only individuals who demonstrated adequate capacity to consent in this study and who chose to participate enrolled. Persons who were initially assessed not to have the capacity to provide informed consent but who wanted to participate were offered a brief educational program based on the one used by Carpenter et al. . After the program was completed, decision-making capacity was again assessed using the MacCAT-CR.
1. Primary Phase 1/1A treatment group comparisons. 27 Chapter 2: Statistical considerations three pair-wise step-down comparisons is protected based on closed testing procedures . 1. 1. 05 by a Hochberg modification to the Bonferroni adjustment for multiple comparisons [5,6]. 050. 05/2). 05/3). Stepping down to the atypical vs. conventional comparisons was considered a secondary rather than primary test. This secondary step had an alternate focus from the primary comparison of the three atypicals, and was a separate family of comparisons.
P-values from the primary analysis were considered inferential, and p-values from all secondary analyses were considered descriptive. Descriptive p-values were presented to identify potential treatment differences without drawing conclusions about statistical significance. All p-values for the tertiary domains were descriptive, exploratory, or hypothesis-generating in nature. For most results reported by the CATIE team, a statistical analysis plan was written prior to beginning the analysis. The plans included an identification of the primary and secondary parameters, the method for treatment group comparisons, as well as the types of statistical analyses to be applied.
Antipsychotic trials in schizophrenia : the CATIE project by T. Scott Stroup, Jeffrey A. Lieberman